Toxic epidermal necrolysis associated with indomethacin therapy.

Toxic epidermal necrolysis associated with deflazacort therapy with nephrotic syndrome

Toxic epidermal necrolysis (TEN) is a drug-related fatal disease. Extensive necrosis of the epidermis can lead to serious complications. This report describes two cases of TEN, associated with deflazacort (DFZ), in two boys, aged 4 years and 14 years, with nephrotic syndrome (NS). The 14-year-old male teenager received DFZ following NS relapse. After 17 days, pruritic papules appeared on the lo...

Toxic epidermal necrolysis associated with streptococcal septicaemia.

[Toxic epidermal necrolysis].

Toxic epidermal necrolysis is a potentially fatal dermatological disease. Large bullae covering extensive areas of the body cause continuous exfoliation of skin, which requires immediate medical attention. Intraoral manifestations may precede cutaneous lesions. Two cases with different treatment protocols are presented.

Toxic Epidermal Necrolysis

Figure 1. Generalized epidermolysis on anterior and posterior torso with crusty erosions on oral mucosa. DESCRIPTION A 33-year-old woman presents with diffuse rash 3 weeks after completing a course of Bactrim for a urinary tract infection. Erythematous maculopapular rash is evident on the trunk and extremities with painful, epidermal sloughing on the back leaving a moist, denuded dermis. Note t...

Intrapartum Toxic Epidermal Necrolysis.

This syndrome was first described by Lyell (1956) in this country and by Lang and Walker (1956) in South Africa and has since been reported with increasing frequency. Beare (1962), in a comprehensive review, collected 35 cases from the published reports and described 10 further cases that he had observed personally. He suggests that it is unlikely that the syndrome could have been seen in the U...